Last update
3/29/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 4 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2,941%
Top Medical Research Studies
4
Vitamin B6 and CFS relationship
We observed the functional status of vitamin B6, also known as pyridoxine, in patients suffering from chronic fatigue syndrome (CFS). Our study involved comparing 12 untreated CFS patients with 18 healthy individuals, matched for age and sex.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
Read More
8
Beta-glucan shows cognitive benefits
We conducted a study exploring the effects of beta-glucan combined with vitamins, including vitamin B6, on individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). This research involved a 36-week trial where 65 participants were split into two groups: one received a daily supplement containing beta-glucan and vitamins, while the other received a placebo.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
Read More
Most Useful Reviews
7.5
Increased energy levels
Excellent quality reduces fatigue and contributes to red blood cell formation, aiding mental functions and immune system performance. It has provided me with more energy during my chronic fatigue syndrome.
Read More
7.5
Mood stabilisation
This Vitamin B-6 supplement is excellent. It boosts my energy during stressful periods and helps stabilise my mood, which is crucial for managing my chronic fatigue syndrome.
Read More
7.5
Improved condition
I took supplements to address iron deficiency during pregnancy, which was crucial for my chronic fatigue syndrome. While it improved my condition, I discontinued after a month due to a skin reaction.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
- All Researches
8
Beta-glucan shows cognitive benefits
We conducted a study exploring the effects of beta-glucan combined with vitamins, including vitamin B6, on individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). This research involved a 36-week trial where 65 participants were split into two groups: one received a daily supplement containing beta-glucan and vitamins, while the other received a placebo.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
Read More
4
Vitamin B6 and CFS relationship
We observed the functional status of vitamin B6, also known as pyridoxine, in patients suffering from chronic fatigue syndrome (CFS). Our study involved comparing 12 untreated CFS patients with 18 healthy individuals, matched for age and sex.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Increased energy levels
Excellent quality reduces fatigue and contributes to red blood cell formation, aiding mental functions and immune system performance. It has provided me with more energy during my chronic fatigue syndrome.
Read More
7.5
Mood stabilisation
This Vitamin B-6 supplement is excellent. It boosts my energy during stressful periods and helps stabilise my mood, which is crucial for managing my chronic fatigue syndrome.
Read More
7.5
Improved condition
I took supplements to address iron deficiency during pregnancy, which was crucial for my chronic fatigue syndrome. While it improved my condition, I discontinued after a month due to a skin reaction.
Read More
6
Adrenal fatigue relief
With chronic fatigue syndrome and adrenal fatigue, I've found that taking approximately 30mg of B6 twice daily seems to be helping significantly.
Read More
Frequently Asked Questions
6
Adrenal fatigue relief
With chronic fatigue syndrome and adrenal fatigue, I've found that taking approximately 30mg of B6 twice daily seems to be helping significantly.
7.5
Mood stabilisation
This Vitamin B-6 supplement is excellent. It boosts my energy during stressful periods and helps stabilise my mood, which is crucial for managing my chronic fatigue syndrome.
7.5
Increased energy levels
Excellent quality reduces fatigue and contributes to red blood cell formation, aiding mental functions and immune system performance. It has provided me with more energy during my chronic fatigue syndrome.
8
Beta-glucan shows cognitive benefits
We conducted a study exploring the effects of beta-glucan combined with vitamins, including vitamin B6, on individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). This research involved a 36-week trial where 65 participants were split into two groups: one received a daily supplement containing beta-glucan and vitamins, while the other received a placebo.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
4
Vitamin B6 and CFS relationship
We observed the functional status of vitamin B6, also known as pyridoxine, in patients suffering from chronic fatigue syndrome (CFS). Our study involved comparing 12 untreated CFS patients with 18 healthy individuals, matched for age and sex.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
References
- Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, et al. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. 10.3390/nu15214504
- Heap LC, Peters TJ, Wessely S. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med. 1999;92:183. PubMed
Data last updated:
